What is CBG?
No, that's not a typo! So what is CBG? CBG (Cannabigerol) is the first cannabinoid that develops in the Cannabis Sativa (hemp and marijuana) plant species and the precursor molecule to the other cannabinoids including THC, CBD and CBC. In fact, all cannabinoids actually stem from CBGa, the acidic version of CBG. It's because of this, CBG is sometimes referred to as "the mother of all cannabinoids".
During the plant's development, cannabinoids synthesise with enzymes (olivetolic acid and geranyl pyrophosphate), and their chemical structures change. For example, CBGa is transformed into THCa, CBDa, CBCa and so on.
Once harvested, the plants are dried using heat or UV light. It is during this process these acidic cannabinoids are broken down into their non-acidic counterparts. For example, THCa converts to THC, CBDa to CBD and CBCa to CBC. This process, known as decarboxylation, is the process responsible for producing the other 100+ plant-based cannabinoids, all of which initially stem from CBGa!
As a result of this ongoing conversion process, isolating and extracting CBG is trickier than most other cannabinoids as generally speaking, only around 1% of a mature Cannabis Sativa plant's cannabinoid content is CBG. Elusive little cannabinoid!
What are the effects of CBG?
As with many other cannabinoids, CBG interacts with our Endocannabinoid Systems. More specifically, it displays both CB1 and CB2 receptor binding affinity; however, it does not interrupt mental faculties. It's important to note here that CBG is non-psychoactive, so it will not get you high and therapeutic doses of CBG consistently appear devoid of side effects.
Dr Bonnie Goldstein, an MD specialising in medical cannabis claims CBG can inhibit GABA uptake in the brain, resulting in muscle relaxation and anti-anxiety effects, similar to the effects CBD can potentially offer. She goes on to also claim CBG appears to have antidepressant and modest antifungal properties, the ability to influence pain and inflammation and more.
Amazing yet unsurprising! As the parent of many other cannabinoids that display therapeutic properties, they have to get their beneficial attributes from somewhere!
Is CBG legal?
Absolutely! As CBG is not scheduled by the Controlled Substances Act or the UN Convention on Psychotropic Substances, CBG is legal in most countries worldwide, including the US and UK.
At present, the amount of research into the therapeutic effects of CBG is somewhat limited; however, promising results have been observed in studies conducted in vitro or using animal models.
In 1990, a study comparing the effects of THC and CBG had on glaucoma displayed "a considerable fall in ocular tension" occurred after administration. Researchers also discovered that "both cannabinoids produced a two to three-fold increase in aqueous outflow facility", concluding that "CBG and related cannabinoids may have therapeutic potential for the treatment of glaucoma".
In 2014, a study published in the Journal of the American Society for Experimental Neurotherapeutics looked at the effects of CBG on simulated Huntington's disease. Results found that "CBG was extremely active as a neuroprotectant in mice, improving motor deficits and preserving striatal neurons" and the researchers concluded these results "open new research avenues".
Another study, published in 2013 in the Journal of Biochemical Pharmacology observed that CBG "could be considered for clinical experimentation in inflammatory bowel disease (IBD) patients."
In 2008, a review of cannabinoids found within the Cannabis Sativa plant showed CBD, CBG, THC, CBN and CBC have intrinsic antibacterial qualities. Collectively, these cannabinoids displayed "potent activity against a variety of methicillin-resistant Staphylococcus".
Flora Farmacy CBG Oil
We are excited to announce we will be adding our very own CBG Oil to our already incredible range of organically grown and lab tested Flora Farmacy products! We expect our CBG Oils to hit the shelves week commencing 15/06/2020.